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Rosetta@home is a distributed computing project for protein structure prediction on the Berkeley Open Infrastructure for Network Computing (BOINC) platform, run by the Baker laboratory at the University of Washington. Rosetta@home also aims to predict protein-protein docking and design new proteins with the help of over 86,000 volunteered computers processing over 68 teraFLOPS on average. Though much of the project is oriented towards basic research on improving the accuracy and robustness of the proteomics methods, Rosetta@home also does applied research on malaria, Alzheimer's disease and other pathologies. Like all BOINC projects, Rosetta@home uses idle computer processing resources from volunteers' computers to perform calculations on individual workunits. Completed results are sent to a central project server where they are validated and assimilated into project databases. The project is cross-platform, and runs on a wide variety of hardware configurations. Users can view the progress of their individual protein structure prediction on the Rosetta@home screensaver. Rosetta@home consistently ranks among the foremost docking predictors, and is one of the best tertiary structure predictors available. (more...)

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